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faq

What is Spirometry?

Why should my child participate in the SIENA study?

Are there any costs or benefits to participating in the SIENA study?

Who is eligible to participate in the SIENA study?

What is Albuterol reversibility in SIENA?

Why is the SIENA study being conducted?

What happens during the SIENA study?

What is sputum induction?

What is exhaled nitric oxide?

How many people will take part in the SIENA study?

What is Spirometry?

Spirometry is a test that measures the amount of air blown out of the lungs and how fast it comes out. During the test, your child will wear a nose clip, take a big breath in and then blow out all their air hard and fast into a machine called a spirometer. You child will be asked to blow into the spirometer several times. This test tells us how well your child’s lungs are working and will be done at each visit.

Why should my child participate in the SIENA study?

Your child’s asthma may or may not improve while in this study. However, the results of this study will help doctors learn more about treating children with asthma in the future. We will give you information about asthma and about staying away from asthma triggers. Your child will receive care from asthma physicians. Your child’s participation could help others with asthma.

Are there any costs or benefits to participating in the SIENA study?

There are no costs to participate in the SIENA study. All study medications will be provided at no charge. Study participation includes breathing tests, asthma medication, and asthma advice from asthma physicians.  There is compensation up to $1,082-$1,267 (if you complete the study). Participants will receive free asthma education.

Who is eligible to participate in the SIENA study?

We are actively recruiting for this study!  If you would like to learn more please contact the study team at 1-866-913-8477 or by email at .(JavaScript must be enabled to view this email address).

Your child may be eligible to participate if he or she is:
12-17 years old and has asthma.

What is Albuterol reversibility in SIENA?

This test measures improvement in your breathing. You will perform spirometry, take 4 puffs of albuterol, and repeat spirometry 15 minutes later. If you show at least 12% improvement in spirometry after 4 puffs of albuterol, a methacholine challenge test will not take place.

Why is the SIENA study being conducted?

The purpose of this study is to find out if people should take an asthma controller medication based on the type of cells present in their airway. We will examine the response to inhaled corticosteroid, which is the standard treatment, and tiotropium, an inhaled medication that has been FDA-approved for COPD (Chronic Obstructive Pulmonary Disease, a smoking related disease that is similar to asthma) but not for asthma, in participants with different types of airway inflammation.

What happens during the SIENA study?

6 study visits and 6 phone contacts over 36 weeks.

Study participation includes asthma tests and lung sputum testing.

If you pass the run-in, you will be given two inhalers. One inhaler is either an inhaled steroid or placebo. The other inhaler is either a long-acting muscarinic antagonist or placebo. Inhalers are described in detail below.

Each person will have 12 weeks on each of the three possible study treatments. The order of these treatments will be decided randomly, like flipping a coin. You and the study staff will not know which treatment you are getting. The treatments include:

1. active mometasone plus placebo tiotropium
2. placebo mometasone plus active tiotropium
3. placebo mometasone plus placebo tiotropium

What is sputum induction?

Your child will take 4 puffs of albuterol before this spit test to open the breathing tubes. Then, your child will be asked to breathe in a salty mist for up to 12 minutes. Every two minutes your child will be asked to cough deeply and strongly in order to bring up mucus (also known as sputum). This test will be done 1 time.

What is exhaled nitric oxide?

The amount of nitric oxide in your breath is thought to increase when the lungs are irritated or inflamed. You will be asked to slowly blow into a mouthpiece attached to a machine that measures nitric oxide.

How many people will take part in the SIENA study?

384 people across the nation will participate in the SIENA study.  Up to 45 people can be enrolled at UCSF