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SIENA- Steroids in Eosinophil Negative Asthma

Most people with asthma have inflammation in their airway. Asthma controller medications, like inhaled corticosteroids, are meant to reduce inflammation in the airway. Reducing airway inflammation should make one’s breathing easier. However, many people with asthma do not breathe easier when they take an inhaled corticosteroid.

We know that there are several types of cells that can cause airway inflammation. However, inhaled corticosteroids mostly target only one cell called the eosinophil. This study aims to find out if people should take an asthma controller medication based on the type of inflammatory cells (called eosinophils) present in their sputum.