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investigators

 

name

Nadav Ahituv, PhD

education

1993 - 1996 Tel-Aviv University, Tel-Aviv, B.Sc. - Biology

1997 - 2002 Tel-Aviv University, Tel-Aviv, Ph.D. with distinction - Human Genetics
 
2002 - 2007 Lawrence Berkeley National Lab, Berkeley, Postdoc - Genomics

specialty

Human genetics, genomics, comparative genomics, gene regulation, noncoding DNA, enhancers, limb malformations, obesity, mouse models, zebrafish, pharmacogenomics.

bio

Assistant Professor, Department of Bioengineering and Therapeutic Sciences, School of Pharmacy, UCSF

Research in our laboratory focuses on understanding the role of regulatory sequences in human biology and disease. Through a combination of comparative genomic strategies, regulatory element analysis, human patient samples, and mouse and fish genetic engineering technologies, we are working to elucidate mechanisms whereby genetic variation within these sequences lead to changes in human phenotypes. The research focuses on three clinically relevant phenotypic categories. The first is monogenic disease, using limb malformations, the second most common form of human congenital abnormalities (prevalence of 1 in every 500 births), as a model. The second is complex disease, analyzing how nucleotide changes in regulatory sequences contribute to obesity. The third is pharmacogenomics, characterizing how genetic differences in regulatory sequences, with a focus on regions surrounding membrane transport proteins, lead to clinical variation in response to drugs. In addition, by both deconstructing known regulatory elements and constructing de novo ones, we are attempting to gain a better understanding of the functional properties of gene regulation.

Dr. Ahituv received undegraduate and graduate tranining in Tel-Aviv University followed by a postdoctoral fellowship in the Lawrence Berkeley National Laboratory. Dr. Ahituv has been a faculty member at UCSF since 2007.

Primary research interests:
Gene regulation and human disease.

Primary clinical interests:
Limb malformations.

Contact:
Nadav Ahituv, PhD
Assistant Professor
Department of Bioengineering and Therapeutic Sciences
Institute for Human Genetics
UCSF
513 Parnassus Ave., Room HSE901H
Box 0794
San Francisco, CA 94143
P: 415 476 1838
F: 415 502 0720
E: .(JavaScript must be enabled to view this email address)
W: http://bts.ucsf.edu/ahituv/



studies